Mechanism of Action

  • Anti-inflammatory effects
    DMSO reduces inflammation by:

    • Scavenging free radicals (molecules that can damage cells).

    • Inhibiting inflammatory cytokines and prostaglandins that contribute to swelling and pain.

  • Analgesic (pain-relief) effects
    DMSO can block peripheral nerve conduction, which dulls the sensation of pain in the area where it's applied.

  • Muscle relaxation
    It may relax muscles and reduce spasms, which can relieve associated pain.

  • Improved circulation and penetration
    DMSO is a powerful solvent that penetrates skin and tissue quickly. It can carry other medications (like anti-inflammatory drugs) through the skin and into deeper tissues, enhancing their effectiveness.

Common Uses

  • Arthritis and joint pain

  • Muscle strains and injuries

  • Interstitial cystitis (used as a bladder instillation)

  • Shingles or nerve pain (off-label)

Dimethyl Sulfoxide

1. Clean the Skin Thoroughly

Wash the application area with unscented soap and warm water, then rinse and dry completely. Avoid lotions, perfumes, or chemicals on the skin — DMSO can carry these into the bloodstream.

2. Apply Using a Clean Material
Use a sterile cotton ball, gauze pad, or clean fingers (wash hands first). Apply a thin layer over the affected area. Gently rub it in, if needed. Do not cover with dirty fabric or plastic; DMSO can pull contaminants into your body.

3. Wait for Absorption

It usually absorbs within 15–20 minutes. A warm, tingling, or garlic taste/smell is common. Leave the area uncovered while it dries.

Frequently Asked Questions

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